VNS Study

Take Part in our Current Bipolar Treatment Study

A Treatment Study for Bipolar Disorder with Vagal Nerve Stimulation
In recent years vagus nerve stimulation (known as VNS) has been shown to be effective in treating issues such as sleep disorders, anxiety, migraines, and more. VNS is a simple and painless at-home intervention that is entirely medication free. Gentle electrical impulses stimulate the vagus nerve, which passes through the ear, causing a mild tingling sensation.
When activated, the vagus nerve system can increase feelings of relaxation and well being.  In general this kind of stress reduction contributes to improvements in wellbeing and resilience.
Until now there has been little research into the use of VNS to treat bipolar disorder, and there has been no research into its effect on Fear of Harm and its symptoms. However, early case studies suggest that non-invasive VNS might have an role to play in reducing symptoms of bipolar disorder and Fear of Harm, and JBRF’s current study seeks to investigate its use.
JBRF is looking for volunteers (or parents of volunteers) ages 6-25 who are willing to take part in this groundbreaking research project. If you’d like to be a part of it, and would like more information please let us know by filling our the brief form below or by emailing us at
Thank you.

The Clinician’s Pathway Program (CPP) and its assessment tools, the CBQ and JJ, were developed by Dr. Demitri Papolos. By clicking the links below you will leave and be redirected to the research site that contains the CPP and the CBQ & JJ assessments. If you have any questions or concerns regarding these tools please direct them to Dr. Papolos’s system administrator at

To Set Up a New CPP Account

To Access an Existing CPP Account

Scoring for assessments within the CPP is a fee-based service offered by the private practice of Demitri Papolos, M.D.; this service is independent of JBRF but may be accessed through the JBRF website. Dr. Papolos developed the CBQ & JJ measures and their automated scoring report with the support of JBRF. Questions and/or concerns with regard to the scored report should be addressed to