RDoC and FOH

If you have the postings on this site about FOH, you will recognize that FOH shares many of the priorities of RDoC:

  • It discards the boundaries of DSM diagnostic classifications
  • It is based on a heritable trait
  • The symptoms which describe it were not conceptually organized but rather sorted themselves into domains or dimensions of behavior
  • All of the symptoms of the syndrome are associated with a specific and important neural circuit
  • Physiological processes such as thermoregulation and metabolism have been identified as critical to the expression of the illness.
  • A deficit in thermoregulation may prove to be the biomarker which would allow for predictable diagnosis.

One of the most unanticipated results of the research has been the important role of thermoregulation to this behavioral disorder. RDoC does not include thermoregulation as one of the dimensions to be explored because members of the steering committees only included those constructs that they felt were most germane to behavioral disorders. We hope to be able to bring compelling data to them soon that thermoregulation should be included in the project.

Undoubtedly the phenotype we are calling FOH will evolve, become more specific and perhaps eventually be called something else altogether. However it is clear that even in its current form, it is an admirable and useful step into this more productive research direction.

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