Over the past several years,

  • JBRF has acquired the world’s largest data set of symptoms experienced by children at risk for, or diagnosed with bipolar disorder.
  • From this, investigators have defined a syndrome called Fear of Harm (FOH) which is based on a heritable trait and describes a severe, often treatment-resistant illness.
  • A majority of the children (and adults) at risk for or diagnosed with bipolar disorder are described by FOH.
  • Investigators have been able to describe a neuroanatomical model of the illness and have determined that problems with body temperature regulation underlie the condition.
  • Studies are underway to explore the observed effectiveness of ketamine to reduce the symptoms of FOH.

In an effort to promote a better understanding of the illness experienced by many children who are at risk for, or diagnosed with bipolar disorder, the JBRF funds research by independent investigators who have come together to form a scientific consortium.

The data used by the consortium comes from the clinical data generated through the JBRF website. Since 2001, JBRF has collected symptom data from over 19,000 affected children. This is a unique resource and the largest source of such information in the world. These large data sets have provided the opportunity for investigators to explore the full and natural expression of illness in these children.

While the journey started off with the goal to better refine an understanding of how bipolar disorder is uniquely experienced by children, the open-minded inquiry ultimately revealed a more profound result.

The research has delineated a new and important profile of behaviors and symptoms which, unlike current classifications of disorders, seems to be an example of a true brain disorder. The syndrome, which is expressed along a spectrum of severity, has been named Fear of Harm (FOH).

Investigators found that the majority of children who are currently diagnosed with bipolar disorder exhibit this condition. It can start at a very young age and follows them into adulthood. This means that FOH is not unique to children nor is it a developmental version of another illness. The adults affected by the condition would be those who are strongly affected by mood disorder but who, like many of the children, would probably (but not necessarily) not qualify for a DSM diagnosis of bipolar disorder. People affected by FOH are often severely impaired by the illness and treatment resistant.

The reason why we make the bold statement that this seems to be a true brain disorder is because the investigators have amassed a significant amount of information regarding the likely neurological and physiological conditions which cause it. Rather than finding disconnected but interesting facts, the research continues to move forward with increasing coherence and depth; both physiologically and neurologically.

Surprisingly, thermoregulation, the system by which the body maintains its proper temperature, has been found to be critical to the expression of this illness. While thermoregulation is not associated with any current psychiatric classification, its profound and complex effect on the body and the brain cannot be dismissed.  Evidence so far demonstrates that children with this condition have a problem with how their bodies dissipate heat. (see FOH and Body Temperature)

The heritable trait of the condition as well as the thermoregulatory hypothesis prompted investigators to select a treatment regimen which appears to be quite effective in treating the syndrome. The reliability with which it reduces the primary symptoms of the syndrome, all of which return when the drug wears off, supports the notion that the syndrome is properly defined.

Studies are ongoing which will hopefully document the safety and efficacy of the treatment as well as provide more data that will validate the syndrome and identify a testable biomarker for the condition.

364 Comments
  1. Pingback: Skydiving NYC
  2. Pingback: pickleball paddles
  3. Pingback: hotels
  4. Pingback: rocky mount
  5. Pingback: interserver coupon
  6. Pingback: interserver coupon
  7. Pingback: click here
  8. Pingback: read more
  9. Pingback: new website
  10. Pingback: useful reference
  11. Pingback: my company
  12. Pingback: a fantastic read
  13. Pingback: original site
  14. Pingback: look at this site
  15. Pingback: More Bonuses
  16. Pingback: Continued
  17. Pingback: Discover More
  18. Pingback: click resources
  19. Pingback: content
  20. Pingback: see post
  21. Pingback: look here
  22. Pingback: best info
  23. Pingback: new website
  24. Pingback: how to
  25. Pingback: about
  26. Pingback: useful reference
  27. Pingback: imp source
  28. Pingback: a fantastic read
  29. Pingback: my response
  30. Pingback: their explanation
  31. Pingback: Visit Website
  32. Pingback: More Bonuses
  33. Pingback: check that
  34. Pingback: you could try here
  35. Pingback: Get the facts
  36. Pingback: official statement
  37. Pingback: important source
  38. Pingback: click here
  39. Pingback: click here
  40. Pingback: click here
  41. Pingback: click here
  42. Pingback: read more
  43. Pingback: read more
  44. Pingback: read more
  45. Pingback: website
  46. Pingback: click here
  47. Pingback: read more
  48. Pingback: official site
  49. Pingback: her latest blog
  50. Pingback: Clicking Here
  51. Pingback: More hints
  52. Pingback: best value
  53. Pingback: new source
  54. Pingback: learn now
  55. Pingback: givehermakeup.com
  56. Pingback: click here
  57. Pingback: read more
  58. Pingback: find
  59. Pingback: figure out
  60. Pingback: continue reading
  61. Pingback: what to do
  62. Pingback: insight
  63. Pingback: quality article
  64. Pingback: quality article
  65. Pingback: Sperry's for women
  66. Pingback: useful reference
  67. Pingback: their explanation
  68. Pingback: Homepage
  69. Pingback: a fantastic read
  70. Pingback: find this
  71. Pingback: browse this site
  72. Pingback: my response
  73. Pingback: More hints
  74. Pingback: Get the facts
  75. Pingback: try this web-site
  76. Pingback: explanation
  77. Pingback: read more
  78. Pingback: check my blog
  79. Pingback: click site
  80. Pingback: my review here
  81. Pingback: useful reference
  82. Pingback: Get More Info
  83. Pingback: see here
  84. Pingback: this website
  85. Pingback: great post to read
  86. Pingback: my company
  87. Pingback: imp source
  88. Pingback: click to read more
  89. Pingback: find more info
  90. Pingback: see it here
  91. Pingback: Homepage
  92. Pingback: a fantastic read
  93. Pingback: find this
  94. Pingback: Bonuses
  95. Pingback: read this article
  96. Pingback: click here now
  97. Pingback: browse this site
  98. Pingback: check here
  99. Pingback: original site
  100. Pingback: my response
  101. Pingback: news
  102. Pingback: click here
  103. Pingback: click here
  104. Pingback: click here
  105. Pingback: click here
  106. Pingback: read more
  107. Pingback: read more
  108. Pingback: read more
  109. Pingback: read more
  110. Pingback: what is new
  111. Pingback: what is new
  112. Pingback: what is new
  113. Pingback: aloe vera for acne
  114. Pingback: aloe vera for acne
  115. Pingback: acne skin
  116. Pingback: click here
  117. Pingback: website
  118. Pingback: important
  119. Pingback: news
  120. Pingback: url
  121. Pingback: niagen
  122. Pingback: click here
  123. Pingback: read more
  124. Pingback: find now
  125. Pingback: news
  126. Pingback: new article
  127. Pingback: best information
  128. Pingback: exceptional
  129. Pingback: see this here
  130. Pingback: Visit Website
  131. Pingback: keep reading
  132. Pingback: home page
  133. Pingback: more about this
  134. Pingback: check my site
  135. Pingback: More Bonuses
  136. Pingback: official statement
  137. Pingback: click reference
  138. Pingback: you can look here
  139. Pingback: her explanation
  140. Pingback: why not try here
  141. Pingback: informative post
  142. Pingback: click here
  143. Pingback: read more
  144. Pingback: info
  145. Pingback: website
  146. Pingback: link
  147. Pingback: best source
  148. Pingback: ebook
  149. Pingback: post
  150. Pingback: next
  151. Pingback: visit site
  152. Pingback: look here
  153. Pingback: Going Here
  154. Pingback: click to read
  155. Pingback: look at here now
  156. Pingback: Extra resources
  157. Pingback: probiotics america
  158. Pingback: Niagen review
  159. Pingback: click here
  160. Pingback: read more
  161. Pingback: website
  162. Pingback: webpage
  163. Pingback: visit them
  164. Pingback: new source
  165. Pingback: important
  166. Pingback: news
  167. Pingback: best info
  168. Pingback: information
  169. Pingback: information
  170. Pingback: news
  171. Pingback: best source
  172. Pingback: best source
  173. Pingback: click here
  174. Pingback: Source
  175. Pingback: have a peek here
  176. Pingback: Check This Out
  177. Pingback: this contact form
  178. Pingback: navigate here
  179. Pingback: weblink
  180. Pingback: this content
  181. Pingback: click here
  182. Pingback: Source
  183. Pingback: have a peek here
  184. Pingback: Check This Out
  185. Pingback: this contact form
  186. Pingback: navigate here
  187. Pingback: check over here
  188. Pingback: this content
  189. Pingback: check my blog
  190. Pingback: his explanation
  191. Pingback: more info here
  192. Pingback: official site
  193. Pingback: look at this site
  194. Pingback: visit
  195. Pingback: check it out
  196. Pingback: see this
  197. Pingback: see this here
  198. Pingback: see this here
  199. Pingback: feres
  200. Pingback: feres inşaat
  201. Pingback: feres gayrimenkul
  202. Pingback: feres
  203. Pingback: feres
  204. Pingback: additional hints
  205. Pingback: Bonuses
  206. Pingback: find more info
  207. Pingback: find more info
  208. Pingback: great post to read
  209. Pingback: my company
  210. Pingback: useful reference
  211. Pingback: my review here
  212. Pingback: click site
  213. Pingback: check my blog
  214. Pingback: this content
  215. Pingback: click here
  216. Pingback: click here
  217. Pingback: midogen review
  218. Pingback: midogen
  219. Pingback: click here
  220. Pingback: niagen reviews
  221. Pingback: niagen
  222. Pingback: click here
  223. Pingback: More Bonuses
  224. Pingback: check my source
  225. Pingback: Check This Out
  226. Pingback: navigate here
  227. Pingback: Source
  228. Pingback: additional reading
  229. Pingback: great post to read
  230. Pingback: more information
  231. Pingback: go now
  232. Pingback: Related Site
  233. Pingback: useful link
  234. Pingback: useful link
  235. Pingback: pop over here
  236. Pingback: Full Article
  237. Pingback: read more
  238. Pingback: pop over here
  239. Pingback: Full Article
  240. Pingback: read more
  241. Pingback: click here
  242. Pingback: pop over here
  243. Pingback: read more
  244. Pingback: pop over here
  245. Pingback: Full Article
  246. Pingback: click here
  247. Pingback: pop over here
  248. Pingback: Full Article
  249. Pingback: Full Article
  250. Pingback: read more
  251. Pingback: click here
  252. Pingback: my review here
  253. Pingback: click site
  254. Pingback: news
  255. Pingback: click here
  256. Pingback: check over here
  257. Pingback: check my blog
  258. Pingback: my company
  259. Pingback: imp source
  260. Pingback: this page
  261. Pingback: Get More Info
  262. Pingback: Homepage
  263. Pingback: great post to read
  264. Pingback: useful reference
  265. Pingback: my review here
  266. Pingback: a fantastic read
  267. Pingback: official site
  268. Pingback: his explanation
  269. Pingback: browse this site
  270. Pingback: dig this
  271. Pingback: read this article
  272. Pingback: original site
  273. Pingback: Bonuses
  274. Pingback: page
  275. Pingback: her latest blog
  276. Pingback: additional hints
  277. Pingback: More Bonuses
  278. Pingback: check over here
  279. Pingback: this content
  280. Pingback: weblink
  281. Pingback: navigate here
  282. Pingback: navigate here
  283. Pingback: this contact form
  284. Pingback: have a peek here
  285. Pingback: rialudi
  286. Pingback: zootopia 2016
  287. Pingback: Source
  288. Pingback: check my blog
  289. Pingback: great post to read
  290. Pingback: see here

Comments are closed.