JBRF Research Publications and Poster Presentations

JBRF investigators are currently conducting studies in the fields of phenomenology (diagnosis), neuroimaging, neuropsychological testing, and molecular genetics. Through our novel Web site, and the screening instruments JBRF researchers have developed, we have been able to collect information on thousands of children with the disorder. This is the largest data base in the world, and it has allowed us to develop a fine-grained view of the illness. This view of the clinical condition informs all of our research studies.

Below, are just a few of the papers recently published in peer-reviewed journals, as well as a collection of research poster presentations at major pediatric bipolar conferences. Several other research papers are in press and will be included here upon publication:

		Fear of harm, a possible phenotype of pediatric bipolar disorder: A dimensional approach to diagnosis for genotyping psychiatric syndromes

		A strategy for identifying phenotypic subtypes: Concordance of symptom dimensions between sibling pairs who met screening criteria for a genetic linkage study of childhood-onset bipolar disorder using the Child Bipolar Questionnaire Research report published in the Journal of Affective Disorders (2007). Suggests a profile of heritable clinical dimensions in addition to classic mood symptomatology in pediatric bipolar disorder. These features may represent a more homogeneous phenotypic subtype of COBPD that may prove more useful for delineating theÊneurobiology and genetics of the disorder than standard diagnostic models.

		The Child Bipolar Questionnaire: A Dimensional Approach to the Assessment of Pediatric Bipolar Disorder Research report published in the Journal of Affective Disorders (2006). Describes the Child Bipolar Questionnaire (CBQ), a rapid method for the early detection of bipolar disorder in children and adolescents. The report documents the findings of excellent reliability and validity of the CBQ in predicting a bipolar diagnosis.

		Factors Associated with Parent-reported Suicide Threats by Children and Adolescents with Community Diagnosed Bipolar Disorder Research report published in the Journal of Affective Disorders in 2005, describes the relationship specific symptoms reported on the Child Bipolar Questionnaire (CBQ) and suicide threats made by children with bipolar disorder. The significance of this finding is that aggression and impulsivity are importantly related to suicidal threats in children and adolescents with bipolar disorder, and that specific items on the CBQ may be predictive of those children at risk.

		Obsessive Fears About Harm to Self or Others and Overt Aggressive Behaviors in Youth Diagnosed with Bipolar Disorder Research report published in the Journal of Affective Disorders in 2005 that describes the strong relationship found between the frequent and intense fears about harm coming to self and others and aggressive behaviors.

		Endophenotypes of a Core Phenotype of Pediatric Bipolar Disorder Poster presented at the NIMH Pediatric Bipolar Disorder Conference (Chicago in 2006). Research from several JBRF-sponsored studies suggests a set of clinical, neuropsychological, and neuroanatomical dimensions of a Core phenotype of juvenile bipolar disorder.

		White Matter Deficits Correlate with Limbic Structural Asymmetry in Pediatric Bipolar Disorder: A Diffusion Tensor Imaging Study Poster presentation at the American Society of Neuroradiology in Toronto (2005), a collaboration between Nathan Klein Institute, Cornell University and JBRF presents MRI data that identify specific brain abnormalities associated with pediatric bipolar disorder.

		Neuroimaging Findings Specific for Bipolar Disorder in Children: Quantitative Structural and Diffusion Tensor Imaging Poster presentation, a research collaboration between Nathan Klein Institute, Cornell University and JBRF indicates that specific imaging findings may be useful in psychiatric differential diagnosis and may ultimately provide a diagnostic tool for resolving an important clinical problem in child psychiatry.

		Behavioral Dimensions of a Core Phenotype Poster presentation at the NIMH Pediatric Bipolar Disorder Conference (April, 2005)

		The Core Phenotype: Identification of a Behavioral Marker Comprised of Aggressive Obsessions and Aggressive Behavior Directed at Self and Others Poster presented at the NIMH Pediatric Bipolar Disorder Conference (April, 2005) Reports research findings that indicate children with bipolar disorder experience intense and recurrent fears about harm befalling themselves and others. Those that have the highest level of fear of harm were found to be the most behaviorally aggressive.

		The Child Bipolar Questionnaire and Four Proposed Phenotypes for Juvenile Bipolar Disorder Poster presented at the NIMH Pediatric Bipolar Disorder Conference (April, 2005) Describes several newer definitions of juvenile-onset bipolar disorder.

		Internet-based Program for the Identification, Assessment and Ascertainment of Affected Sibling Pairs Poster presented at the NIMH Pediatric Bipolar Disorder Conference (April, 2004). Describes the JBRF web-based data acquisition program. The program now supports a database of over 5000 children.

		Expert Diagnostic Workshop on Juvenile Bipolar Disorder Poster presented at the NIMH Pediatric Bipolar Disorder Conference (April, 2004) Describes a web-based program, The Expert Diagnostic Workshop, developed to provide international experts in juvenile-onset bipolar disorder with a forum to discuss and diagnose cases using several alternate criteria. It is hoped that the workshop will help to build a much-needed consensus of opinion on the definition of bipolar disorder in children and adolescents.

		Parent Reported Obsessive-compulsive Behavior Obtained via an Internet Based Acquisition System Poster presented at the NIMH Pediatric Bipolar Disorder Conference (April, 2004) Documents the rates of obsessions and compulsions reported by parents of bipolar children on the JBRF web-based data acquisition program.

		Assessment of Obsessive-compulsive Behavior in Childhood-onset Bipolar Disorder Poster presented at a Depression Consortium in Pittsburgh (2003).

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