Q&A on the significance of the longitudinal study of intranasal ketamine in a novel phenotype of bipolar disorder

Clinical experience using intranasal ketamine in the longitudinal treatment of juvenile bipolar disorder with fear of harm phenotype. Papolos D1, Frei M2, Rossignol D3, Mattis S4, Hernandez-Garcia LC5, Teicher MH5.J Affect Disord. 2017 Aug 30. 1. Were you surprised by your findings, why, why not? I was surprised by the magnitude of the effect when…

How ketamine works to treat depression

Shots – Health Blog: NPR – Andrew Prince   Traditional antidepressants like Prozac work on a group of chemical messengers in the brain called the serotonin system. Researchers once thought that a lack of serotonin was the cause of depression, and that these drugs worked simply by boosting serotonin levels. Recent research suggests a more…

Antidepressant-induced mania studies

The relationship between use of antidepressants and resource utilization among patients with manic or mixed bipolar disorder episodes: Findings from a managed care setting Self-Reported History of Manic/Hypomanic Switch Associated with Antidepressant Use: Data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) A Pilot Study of Antidepressant-Induced Mania in Pediatric Bipolar Disorder: Characteristics,…